Cyanide antidote kit burn1/15/2024 ![]() ![]() Measurement of vital signs showed a blood pressure of 90/65 mmHg, a respiratory rate of 18 breaths per minute, and a heart rate of 102 beats per minute. She was immediately intubated using a glideslope for airway protection. She was found to have a Glasgow Coma Scale (GCS) score of 5. Upon admission, she showed signs of inhalational injury, a black discoloration around her mouth and nostrils, and a first-degree burn on the left side of her neck. These patients have the potential for cognitive recovery.Ī healthy 45-year-old Yemeni woman was brought to the Accident and Emergency Department (ED) at King Saud University Medical City after being trapped in a closed space in her house for one hour while furniture was burning before the fire department and paramedics extracted her from the room. This study describes the long-term neuropsychiatric sequelae in a survivor of cyanide toxicity due to inhalation, as assessed by arterialization. Assays of venous blood gases may aid in the diagnosis of cyanide poisoning . Because the early clinical manifestations of cyanide intoxication are often nonspecific, emergency physicians must recognize the physiological abnormalities characteristic of cyanide poisoning. These neurological aspects of cyanide poisoning can also be analyzed by structural neuroimaging . Cyanide toxicity should be suspected in smoke inhalation patients with two or more of the signs of neurological dysfunction, such as changes in mental status, loss of consciousness, and seizure activity . Although some natural products such as silk and wool can release cyanide when burned, practically any substance with carbon and nitrogen can release cyanide when burned . ![]() ![]() The arterialization of venous blood gases may serve as an early clue to the diagnosis of cyanide poisoning.Ĭyanide is a lethal compound because it binds to ferric iron in cytochrome oxidase a3, thereby inhibiting oxidative phosphorylation, which leads to the depletion of intracellular adenosine triphosphate (ATP) . Magnetic resonance imaging (MRI) can show the extent and structure of lesions in cyanide-sensitive regions of the brain, but it is not always diagnostic. Even after three months of treatment and continuous follow-up, she still showed signs of mild cognitive memory impairment along with word-finding difficulties and focal dystonia of her right hand.įull neurological and cognitive assessments are crucial to determine the neuropsychiatric sequelae of acute cyanide toxicity. She experienced neuropsychiatric sequelae of cyanide poisoning, with deficits evolving over three months. Upon admission, she displayed signs of inhalational injury, a black discoloration around her mouth and nostrils, and a first-degree burn on the left side of her neck. This report describes the case of a healthy 45-year-old Yemeni woman who was present during the burning of furniture in a closed space in her home. Most patients who survive cyanide poisoning experience neurological sequelae. Some natural products such as silk and wool can release cyanide when burned. Cyanide is one of the most rapidly acting poisons and accounts for many suicidal and homicidal deaths. ![]()
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